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[Flupenthixol versus haloperidol in acute psychotic episodes]
Acta Psychiatrica Belgica
|January 1, 1982
Summary
Flupentixol and haloperidol show strong antipsychotic effects. Flupentixol demonstrated a faster onset and improved anxiety, depression, and defect symptoms in schizophrenic patients, with extrapyramidal side effects common to both.
Area of Science:
- Psychiatry and Pharmacology
Background:
- Antipsychotic medications are crucial for managing acute psychosis.
- Understanding dose-response relationships and specific symptom profiles is essential for effective treatment.
Purpose of the Study:
- To evaluate the activity of flupentixol oral high concentration.
- To define the drug's profile based on administered dosage.
- To compare flupentixol with haloperidol in acute psychiatric patients.
Main Methods:
- An open-label, randomized trial involving 40 acute patients (schizophrenia, mania, other psychoses).
- Patients were randomly assigned to receive either haloperidol or flupentixol.
- Activity and side effects were monitored based on administered doses.
Main Results:
- Both flupentixol and haloperidol exhibited significant antipsychotic and antimanic effects.
- Flupentixol showed a quicker onset of action in schizophrenic patients.
- Flupentixol demonstrated more pronounced activity in reducing anxiety, depressive tendencies, and defect symptoms in schizophrenic patients.
- Extrapyramidal side effects were the most frequently observed adverse events for both drugs.
Conclusions:
- Flupentixol is an effective antipsychotic and antimanic agent.
- Flupentixol offers advantages in terms of faster onset and broader symptom improvement in schizophrenia.
- Both drugs share similar common side effect profiles, primarily extrapyramidal symptoms.