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A new phosphorylation method for the nucleotide synthesis

Y Hayakawa, Y Aso, M Uchiyama

    Nucleic Acids Symposium Series
    |January 1, 1982
    PubMed
    Summary
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    A new method synthesizes nucleoside phosphates using mild phosphorylating agents and nucleoside metal alkoxides. This approach is effective for creating dinucleotides, advancing nucleotide chemistry.

    Area of Science:

    • Nucleotide Chemistry
    • Organic Synthesis
    • Biochemistry

    Background:

    • Nucleoside phosphates are crucial biomolecules.
    • Existing synthesis methods can be harsh or inefficient.

    Purpose of the Study:

    • To develop a novel and milder method for synthesizing nucleoside phosphates.
    • To demonstrate the utility of this method in dinucleotide synthesis.

    Main Methods:

    • Reaction of nucleosides with metal alkoxides.
    • Phosphorylation using mild agents like phosphorochloridates or p-nitrophenyl phosphates.

    Main Results:

    • Successfully synthesized various nucleoside phosphates.
    • Demonstrated the applicability of the method for dinucleotide formation.

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    Conclusions:

    • This new synthetic route offers an efficient entry to nucleoside phosphates.
    • The method is a valuable tool for constructing complex nucleotide structures like dinucleotides.