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[Acquired leukomelanoderma caused by topical depigmenting agents]
Annales De Dermatologie Et De Venereologie
|January 1, 1982
Summary
Monobenzyl ether (MBEH) cream causes depigmentation in patients with hyperpigmentary disorders. This agent can lead to irreversible melanocyte damage and distant depigmentation, with potential for permanent skin color changes.
Area of Science:
- Dermatology
- Toxicology
- Cell Biology
Background:
- Acquired hyperpigmentary disorders are treated with monobenzyl ether of hydroquinone (MBEH) and monomethyl ether of hydroquinone.
- MBEH's depigmenting ability was discovered in 1939 following an occupational accident involving rubber gloves.
Observation:
- Patients treated with MBEH experienced local and distant depigmentation.
- Adverse effects included irritation, sensitization, and melanoleukodermia in Asian patients.
Findings:
- MBEH causes irreversible damage to melanocytes through free radical formation and lipid peroxidation.
- Electron microscopy reveals cellular disturbances in melanosomes and intracytoplasmic membrane degeneration.
Implications:
- MBEH's mechanism involves selective incorporation into melanocytes and subsequent cell death.
- The potential for permanent depigmentation necessitates careful consideration in treating hyperpigmentary disorders.