[Development of atherosclerosis in alternating prolonged electrostimulation of the negative and positive hypothalamic...

Rabbits kept under conditions of free behavior were exposed to long-term electrostimulation of negative and positive emotiogenic zones of the hypothalamus by means of a special autonomous nutrition system. It is shown that long-term electrostimulation of the negative emotiogenic hypothalamic zones followed by rest causes disorders of lipid metabolism and vascular permeability and the development of atherosclerosis. The development of atherosclerosis intensifies in alternated electrostimulation of the negative and positive emotiogenic zones and rest. Electrostimulation of the positive emotiogenic hypothalamic zones does not induce atherogenic changes in the vessels. It is suggested that the atherogenic lipoproteins infiltrate into the aorta after the cessation of negative emotional stress attended by the development of positive emotional states and rest.