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Related Experiment Videos

Diurnal variation in pulmonary diffusing capacity and expiratory volumes

A Panda, G McHardy

    Indian Journal of Physiology and Pharmacology
    |April 1, 1980
    PubMed
    Summary

    Pulmonary diffusing capacity for Carbonmonoxide (DLCO) and lung function tests (FEV1, FVC) showed significant diurnal variations in healthy adults. These lung function measurements exhibit a clear daily rhythm, impacting their values throughout the day.

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    Area of Science:

    • Pulmonary physiology
    • Respiratory medicine
    • Chronobiology

    Background:

    • Lung function tests like DLCO, FEV1, and FVC are crucial for assessing respiratory health.
    • Understanding diurnal variations in these parameters is important for accurate interpretation and clinical decision-making.

    Purpose of the Study:

    • To investigate the diurnal rhythm of pulmonary diffusing capacity for Carbonmonoxide (DLCO) in healthy individuals.
    • To determine if lung function parameters such as forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) also exhibit diurnal variations.

    Main Methods:

    • DLCO was measured in 20 healthy volunteers at 9 a.m., 12 noon, and 5 p.m.
    • FEV1 and FVC were measured after each DLCO assessment.
    • Statistical analysis was performed to evaluate the significance of observed variations.

    Main Results:

    • A statistically significant fall in mean DLCO was observed at noon compared to morning values.
    • DLCO values at 5 p.m. were similar to noon values, indicating a sustained reduction.
    • FEV1 and FVC demonstrated similar trends, decreasing in the afternoon.

    Conclusions:

    • The study suggests that DLCO, FEV1, and FVC exhibit a diurnal rhythm in healthy adults.
    • These findings highlight the importance of considering the time of day when interpreting lung function test results.
    • Diurnal variations in lung function may have implications for disease monitoring and treatment strategies.

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