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Secondary syphilis with iris papules

L K Schwartz, G R O'Connor

    American Journal of Ophthalmology
    |September 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Syphilis can cause eye inflammation, specifically iridocyclitis with iris lesions. Treatment with penicillin and anti-inflammatory drugs resolved the condition, but angiography revealed persistent vascular changes.

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    Area of Science:

    • Ophthalmology
    • Infectious Diseases
    • Immunology

    Background:

    • Secondary syphilis can manifest with ocular complications, including iridocyclitis.
    • Iris involvement in syphilis may present as roseolae and papules.

    Observation:

    • A patient developed bilateral iridocyclitis with characteristic iris lesions three months post-secondary syphilis rash.
    • Serum immune-complex levels were mildly elevated.
    • Iris angiography demonstrated fluorescein leakage in affected iris regions and pupillary margin vessels.

    Findings:

    • The inflammation resolved with a combination of penicillin, topical corticosteroids, and cycloplegics.
    • Follow-up iris angiography revealed persistent fluorescein leakage from previously affected iris areas, even in the absence of clinical inflammation.

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    Implications:

    • This suggests a persistent inflammatory effect on iris vasculature following syphilis-induced iridocyclitis.
    • Ocular syphilis requires thorough investigation and management, considering potential long-term vascular sequelae.