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Serum hydrocortisone (cortisol) values in glaucomatous and normotensive Beagles
American Journal of Veterinary Research
|September 1, 1980
Summary
Glaucomatous Beagles show significantly higher serum cortisol levels compared to healthy dogs. These elevated cortisol levels in glaucoma patients correlate with increased intraocular pressure but lack diurnal variation.
Area of Science:
- Veterinary Ophthalmology
- Endocrinology
Background:
- Glaucoma is a significant ocular disease in Beagles.
- Serum cortisol (hydrocortisone) is a key stress hormone with potential links to ocular conditions.
Purpose of the Study:
- To investigate serum cortisol levels in Beagles with glaucoma.
- To compare cortisol levels between glaucomatous and normotensive Beagles.
- To explore the relationship between cortisol levels, intraocular pressure, and diurnal variations.
Main Methods:
- Serum cortisol was measured using radioimmunoassay.
- Measurements were taken at four time points: 1 AM, 7 AM, 1 PM, and 7 PM.
- Included 20 glaucomatous and 5 normotensive Beagles.
Main Results:
- Glaucomatous Beagles had significantly higher mean serum cortisol (20.9 ng/ml) than normotensive Beagles (9.5 ng/ml) (P < 0.01).
- Elevated serum cortisol in glaucomatous Beagles at 1 AM and 7 AM correlated with increased intraocular pressure.
- No significant diurnal variations in serum cortisol were observed in either group.
Conclusions:
- Beagles with glaucoma exhibit elevated serum cortisol levels.
- The increase in cortisol may be associated with intraocular pressure elevation in canine glaucoma.
- Further research is needed to understand the implications of these findings and the absence of diurnal cortisol rhythm.