Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pontosubicular necrosis and hyperoxemia

M Ahdab-Barmada, J Moossy, M Painter

    Pediatrics
    |December 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Pontosubicular necrosis (PSN) in newborns is linked to high blood oxygen levels (hyperoxemia) after birth. This condition, seen in premature infants, may result from reduced cerebral blood flow or increased oxygen toxicity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Micro-CT for saw mark analysis on human bone.

    Forensic science international·2018
    Same author

    Administrative incidence of psychosis assessed in an early intervention service in England: first epidemiological evidence from a diverse, rural and urban setting.

    Psychological medicine·2011
    Same author

    Detrimental cerebrometabolic effects of hyperoxia in newborn rats.

    Neurochemistry international·2010
    Same author

    Cognitive behaviour therapy for improving social recovery in psychosis: a report from the ISREP MRC Trial Platform Study (Improving Social Recovery in Early Psychosis).

    Psychological medicine·2009
    Same author

    ABC transporter (P-gp/ABCB1, MRP1/ABCC1, BCRP/ABCG2) expression in the developing human CNS.

    Neuropediatrics·2009
    Same author

    Uptake of pneumococcal polysaccharide vaccine in at-risk populations in England and Wales 1999-2005.

    Epidemiology and infection·2007
    Same journal

    Severe Postoperative Hypernatremia in an Adolescent Following Sleeve Gastrectomy.

    Pediatrics·2026
    Same journal

    Barriers to Implementing SMART for Asthma in Pediatric Primary Care.

    Pediatrics·2026
    Same journal

    Blood Lead Testing Among Children Enrolled in Medicaid.

    Pediatrics·2026
    Same journal

    From Screening to Support: Crafting Social Needs Response Systems That Work for Families.

    Pediatrics·2026
    Same journal

    A Social Care Intervention in Pediatric Practices: A Stepped Wedge Cluster Trial.

    Pediatrics·2026
    Same journal

    Pediatric Cheerleading-Related Head Injuries and the "Double Down" Rule Change.

    Pediatrics·2026
    See all related articles

    Area of Science:

    • Neonatal pathology
    • Perinatal neurology
    • Pediatric critical care

    Background:

    • Pontosubicular necrosis (PSN) is a perinatal brain injury.
    • It is associated with birth asphyxia and affects the pons and hippocampus.
    • The exact triggers during the critical perinatal period require further investigation.

    Purpose of the Study:

    • To investigate the association between high arterial blood oxygen levels (hyperoxemia) and the incidence of PSN in neonates.
    • To determine if hyperoxemia is a risk factor for PSN in the first week of life.

    Main Methods:

    • Retrospective review of neonatal autopsies and clinical data from 1977.
    • Analysis of 64 neonates with multiple PO2 measurements, categorized by sustained PO2 levels (>150 torr vs. ≤150 torr).

    Related Experiment Videos

  • Correlation of PSN severity with gestational age (26-36 weeks).

    • Main Results:

    • PSN was absent in neonates with PO2 ≤150 torr (Group I).
    • PSN was prominent in neonates with sustained PO2 >150 torr (Group II).
    • PSN was most severe in infants between 26-36 weeks gestational age.

    Conclusions:

    • High arterial PO2 levels in the first week of life are strongly associated with PSN in neonates.
    • Hyperoxemia may impair cerebral blood flow or increase oxygen toxicity in vulnerable preterm infants.
    • This suggests a critical window for oxygen management in high-risk newborns.