[Brain and spinal cord nitrogen metabolism in chronic alcoholism following strenuous physical exertion]

Development of the fatigue state in rats, subjected to prolonged alcohol intoxication, after swimming with might led to dissimilar alterations in the system of ammonia formation and binding in brain and spinal cord as compared with control animals under the same conditions of loading. Within the first minutes of the heavy loading the faster and more distinct accumulation of ammonia was observed, then the rapid exhaustion of the reaction occurred and the ammonia production was markedly decreased in the state of fatigue. Impairments in brain protein deamidation and decrease in content of urea were found. At the same time, dynamics of gamma-aminobutyric acid, dicarboxylic amino acids and their amides was altered.