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Lidocaine aerosols do not prevent allergic bronchoconstriction
Anesthesia and Analgesia
|January 1, 1981
Summary
Local anesthetic aerosols, like lidocaine, did not protect against asthma attacks triggered by allergens in dogs. However, they did block irritant reflexes, suggesting insufficient lung concentration for direct smooth muscle relaxation.
Area of Science:
- Pulmonary medicine
- Pharmacology
Background:
- Asthma involves bronchoconstriction.
- Local anesthetics are explored for asthma treatment.
Purpose of the Study:
- To evaluate lidocaine aerosol efficacy in preventing antigen-induced bronchoconstriction in a canine asthma model.
Main Methods:
- Dogs were sensitized and challenged with Ascaris antigen aerosols.
- Pulmonary resistance was measured after lidocaine or saline aerosol administration.
- Blood lidocaine levels were quantified.
Main Results:
- Lidocaine aerosols did not prevent antigen-induced bronchoconstriction.
- Lidocaine aerosols effectively blocked citric acid-induced irritant reflexes.
- Achieved blood lidocaine levels were 0.6-3.3 µg/ml.
Conclusions:
- Inhaled lidocaine at tested concentrations is ineffective for allergen-induced asthma.
- Lidocaine aerosols may block airway irritant reflexes but not smooth muscle contraction in asthma.