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Structure-activity relationship of isatin Mannich bases and hydrazones
Arzneimittel-Forschung
|January 1, 1980
Abstract:
35 isatin Mannich bases and hydrazones were tested fore their mitodepressant activity applying a phyto test with Lepidium sativum L. The obtained results were subjected to the Free-Wilson's analysis. Although calculated and experimentally determined mitodepressant activities differ considerably in some cases, there is a correlation (r = 0.94) between the studied structures and mitodepressant activities.