Cardiovascular activity of a deproteinized blood extract

The cardiovascular effects of the deproteinized blood extract were investigated in anaesthetized dogs: respiration, general metabolism and systemic haemodynamics were tested and the changes in these parameters after the administration of the drug were studied. At 2 ml kg-1 i.v., the deproteinized blood extract induced a transient drop in arterial blood pressure and bradycardia. On the other hand, the total peripheral resistance and the elastic resistance, of the arteries were decreased and this effect was of longer duration. Moreover, the deproteinized blood extract stimulated the myocardium contractile force and dc/dt and increased the cardiac performances. The mechanism of action of this drug is discussed.