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Lisuride in parkinsonism

G Gopinathan, H Teräväinen, J M Dambrosia

    Neurology
    |April 1, 1981
    PubMed
    Summary
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    Lisuride, a dopaminergic ergot derivative, improved motor symptoms like akinesia, rigidity, and tremor in parkinsonian patients. Most tolerated up to 5 mg daily, though somnolence was more frequent than with other treatments.

    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Parkinson's disease is a neurodegenerative disorder affecting motor control.
    • Dopaminergic agents are a cornerstone of Parkinson's disease treatment.

    Purpose of the Study:

    • To evaluate the efficacy and tolerability of lisuride in patients with Parkinson's disease.

    Main Methods:

    • A study involving 20 parkinsonian patients.
    • Gradual dose escalation of lisuride up to 5 mg daily.
    • Clinical assessments and computer-assisted objective evaluations.

    Main Results:

    • Most patients tolerated daily doses of up to 5 mg of lisuride.
    • Significant improvements were observed in akinesia, rigidity, and tremor.

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  • Adverse reactions were comparable to levodopa and bromocriptine, with increased somnolence.

    • Conclusions:

    • Lisuride demonstrates therapeutic potential for managing Parkinson's disease motor symptoms.
    • Tolerability is generally good, but increased somnolence requires consideration.