[A dosage regimen for epicillin in renal impairment (author's transl)]

After oral administration of 1 g 6-[D-2-amino-2-(cyclohexa 1,4-dien-1-yl)-acetamido]-penicillanic acid (epicillin Spectacillin capsules, 500 mg) in patients with renal impairment the elimination rate constant was calculated by means of the declining serum levels. There is good correlation (r = 0.83) between the elimination rate constant and the creatinine clearance. With this data it was possible to calculate the reduced loading and maintenance dose for a certain creatinine clearance and a certain dosage interval to avoid accumulation. The values could also be read from nomograms without calculation. For comparison the possibility to extend the dosage interval corresponding to the elimination rate constant in renal impairment is confronted.