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[Photosensitization by Benoxaprofen (author's transl)]
Arzneimittel-Forschung
|January 1, 1981
Summary
The antirheumatic drug benoxaprofen can cause skin phototoxicity and nail damage (onycholysis) after sun exposure. These side effects were mitigated by specific sunscreen and nail varnish treatments.
Area of Science:
- Dermatology
- Pharmacology
- Photobiology
Context:
- Benoxaprofen (Coxigon), an antirheumatic drug, is associated with photosensitivity.
- Phototoxic reactions and onycholysis are potential side effects observed in patients.
Purpose:
- To investigate the phototoxic reactions and onycholysis induced by benoxaprofen.
- To evaluate the efficacy of protective measures against these side effects.
Summary:
- Benoxaprofen ingestion can lead to immediate phototoxic skin reactions and partial onycholysis, with incidences of 3% and 1% respectively in Central Europe.
- Clinical trials and experimental UVA irradiation revealed transient skin burning and erythema after recommended doses.
- Topical application of benoxaprofen did not induce photosensitization, suggesting a systemic mechanism.
Impact:
- Photosensitization can be effectively prevented using UVA-absorbing sunscreens.
- Onycholysis can be managed with opaque nail varnishes.
- Understanding the pathogenesis of benoxaprofen-induced phototoxicity is crucial for patient safety.