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Plasminogen activator in the rodent brain

H Soreq, R Miskin

    Brain Research
    |July 20, 1981
    PubMed
    Summary

    Protease plasminogen activator (PA) in the rodent brain originates from neurons and epithelial cells. This enzyme shows dynamic developmental patterns and potential functions beyond blood clot breakdown.

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Developmental Biology

    Background:

    • The enzyme plasminogen activator (PA) plays a role in the brain, but its cellular origins and developmental roles are not fully understood.
    • Investigating PA's properties is crucial for understanding brain function and potential therapeutic targets.

    Purpose of the Study:

    • To determine the cellular origin(s) of protease plasminogen activator (PA) in the rodent brain.
    • To characterize the biochemical properties and developmental patterns of brain PA.
    • To explore potential functions of PA beyond thrombolysis.

    Main Methods:

    • Localization of PA activity using a novel autoradiography technique in rodent brain sections.
    • Quantification of PA levels and electrophoretic mobility in brain homogenates from different developmental stages.

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  • Assessment of PA localization and activity in X-irradiated brain regions.

    • Main Results:

    • PA activity was localized to neuronal cell bodies and endothelial, meningeal, and ependymal layers.
    • PA levels exhibited transient increases with region-specific rates and timing during development.
    • X-irradiation affected neuronal PA but not epithelial cell PA, suggesting distinct origins and regulation.

    Conclusions:

    • Protease plasminogen activator (PA) is produced by both neurons and epithelial cells in the brain.
    • PA exhibits dynamic developmental expression and may have functions independent of thrombolysis.
    • These findings offer insights into the multifaceted roles of PA in both developing and mature brains.