[Hyperglycemia as a risk factor in pregnancy (author's transl)]

Glycosylated hemoglobins were used for the retrospective assessment of glucose metabolism, for therapy control, and as predictor of the weight of the newborn. Glycosylated hemoglobins were determined with the microcolumn method in 50 pregnant diabetics, in 11 overweight pregnant women, in 11 pregnant women under tocolytic treatment, and in 28 metabolically healthy women. Whereas the levels of glycosylated hemoglobins were found to be reduced in metabolically healthy women, the corresponding levels were increased in tocolytically treated, adipose, and diabetic pregnant women. The HbAI values correlated with the mean values of the daily blood glucose profiles (r = 0.79 - 0.94) and decreased during improvement of the metabolic state. A statistic correlation could not be established between the maternal HbAI and the weight of the newborn as the pregnancy period is shortened by dearrangement of the carbohydrate metabolism.