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Dapsone-responsive, noninfectious verrucous pyoderma. Its occurrence following cisplatin therapy
Archives of Dermatology
|May 1, 1982
Summary
A rare skin condition, a noninfectious pyoderma, appeared on a patient's hands after receiving cisplatin chemotherapy for bladder cancer. This eruption, resembling erythema elevatum diutinum, responded well to dapsone treatment.
Area of Science:
- Dermatology
- Oncology
- Clinical Medicine
Background:
- Metastatic bladder carcinoma presents significant treatment challenges.
- Cisplatin chemotherapy is a common treatment modality for advanced bladder cancer.
- Cutaneous adverse events can occur during cancer therapy.
Observation:
- A 66-year-old male with metastatic bladder carcinoma developed a nodular, centrally verrucous pyoderma on his dorsal hands and fingers.
- The dermatosis emerged following palliative cisplatin therapy.
- The clinical presentation mimicked erythema elevatum diutinum.
Findings:
- Biopsy did not reveal significant leukocytoclastic vasculitis, differentiating it from typical erythema elevatum diutinum.
- The pyoderma demonstrated a positive response to dapsone treatment.
- The exact role of cisplatin in inducing this specific dermatosis remains speculative.
Implications:
- This case highlights a potential, albeit speculative, association between cisplatin therapy and a unique pyoderma.
- Dapsone may be an effective treatment for this specific cisplatin-induced dermatosis.
- Further research is warranted to elucidate the mechanisms underlying chemotherapy-induced skin reactions.