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Sarcoid optic neuropathy

S K Gudeman, J B Selhorst, J O Susac

    Neurology
    |June 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Sarcoidosis can cause optic neuropathy, leading to vision loss. Early diagnosis of sarcoid optic neuropathy may be possible without surgery, based on clinical findings.

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    Area of Science:

    • Ophthalmology
    • Neurology
    • Immunology

    Background:

    • Unilateral progressive optic neuropathy can present with symptoms localized to the optic nerve.
    • Meningioma is a common differential diagnosis for optic nerve sheath lesions.

    Observation:

    • Three patients with unilateral optic neuropathy initially suspected to have meningioma were evaluated.
    • Clinical and imaging findings suggested optic nerve involvement at the orbital-canalicular or intracranial segments.

    Findings:

    • Surgical exploration revealed noncaseating granulomas, indicative of sarcoidosis, in two patients.
    • Granulomatous invasion of the retrobulbar optic nerve is an uncommon presentation of sarcoidosis.

    Implications:

  • These cases suggest that sarcoid optic neuropathy can mimic meningioma.
  • A nonsurgical diagnostic approach for sarcoid optic neuropathy may be feasible, potentially avoiding unnecessary surgical intervention.