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Related Experiment Videos

Tilidine abuse and dependence

A Trojan, H W Beil

    Drug and Alcohol Dependence
    |November 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Tilidine, a strong analgesic, became a substitute for opiates, leading to dependence even in non-addicted patients. This review covers tilidine

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    Area of Science:

    • Pharmacology
    • Clinical Medicine
    • Public Health

    Background:

    • Tilidine (Valoron) introduced in West Germany in 1970 as a potent analgesic.
    • Rapidly became a substitute for opiates on the drug scene.
    • Placed under German Narcotics Act in February 1978 due to abuse potential.

    Purpose of the Study:

    • To review the literature on tilidine dependence and abuse.
    • Examine pharmacological, epidemiological, and clinical aspects.
    • Highlight the emergence of tilidine as a drug of abuse.

    Main Methods:

    • Literature review.
    • Analysis of pharmacological data.
    • Epidemiological data assessment.
    • Clinical case review.

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    Main Results:

    • Tilidine dependence identified in patients without prior addiction history.
    • Tilidine abuse emerged as a significant issue.
    • Pharmacological and clinical factors contributing to dependence were noted.

    Conclusions:

    • Tilidine poses a risk of dependence, even in naive individuals.
    • Understanding the abuse potential is crucial for clinical and regulatory purposes.
    • Further research into prevention and management of tilidine abuse is warranted.