Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Theoretical error in radionuclide ejection fraction study due to photon attenuation

E L Yeh, Y S Yeh

    European Journal of Nuclear Medicine
    |February 1, 1981
    PubMed
    Summary

    Radionuclide ejection fraction measurements are often lower than X-ray contrast methods due to photon attenuation. Adding 5 percentage points to radionuclide ejection fraction values improves correlation with X-ray contrast studies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Impact of Mandatory Clinical Ethics Consultation for Neurocritically Ill Patients.

    Journal of bioethical inquiry·2026
    Same author

    New measurement of antineutrino oscillation with the full detector configuration at Daya Bay.

    Physical review letters·2015
    Same author

    Search for a light sterile neutrino at Daya Bay.

    Physical review letters·2014
    Same author

    Spectral measurement of electron antineutrino oscillation amplitude and frequency at Daya Bay.

    Physical review letters·2014
    Same author

    Radionuclide demonstration of urinary extravasation with ureteral obstruction.

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2013
    Same author

    Distortion of bar-phantom image by collimator.

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2013

    Area of Science:

    • Nuclear medicine
    • Radiology
    • Cardiovascular imaging

    Background:

    • Ejection fraction (EF) is a key metric for assessing cardiac function.
    • Discrepancies exist between radionuclide ventriculography (RNV) and X-ray contrast ventriculography (XCV) EF measurements.
    • Photon attenuation in RNV may lead to underestimation of EF.

    Purpose of the Study:

    • To investigate the cause of lower ejection fractions measured by the radionuclide method compared to the X-ray contrast method.
    • To quantify the error introduced by photon attenuation in radionuclide ejection fraction studies.
    • To propose a correction method for improving the accuracy of radionuclide ejection fraction measurements.

    Main Methods:

    • Comparison of ejection fraction measurements obtained from radionuclide imaging and X-ray contrast ventriculography.

    Related Experiment Videos

  • Mathematical modeling to calculate the error due to photon attenuation in the radionuclide method.
  • Analysis of ventricular volumes at end-diastole and end-systole to assess attenuation effects.

    • Main Results:

    • Radionuclide ejection fractions were consistently lower than those from X-ray contrast.
    • Photon attenuation by cardiac blood pool and soft tissue was identified as a primary cause.
    • Mathematical calculation indicated an average error of approximately 5 percentage points due to photon attenuation.
    • Adding a 5 percentage point correction to radionuclide EF values improved correlation with X-ray contrast results.

    Conclusions:

    • Photon attenuation significantly impacts radionuclide ejection fraction accuracy.
    • A simple correction factor of 5 percentage points can enhance the clinical utility of radionuclide EF measurements.
    • The principles of photon attenuation correction may be applicable to other nuclear medicine studies, such as residual urinary bladder volume assessment.