Synthesis of some substituted pyrido[1,2-a][1,8]naphthyridines

Synthesis of a pyrido[1,2-a][1,8]naphthyridine (VII) was achieved starting from 7-amino-2,4-dimethyl-1,8-naphthyridine and diethyl ethoxymethylenemalonate. Some derivatives were subjected to pharmacological screening.