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Updated: Sep 30, 2026

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
Published on: March 8, 2017
[The indications for middle ear instillation of gentamicin in Menière's disease (author's transl)]
Abstract:
Menière's disease treated by use of Gentamicin sulphate instillation into the middle ear is reported. This drug is injected via a small plastic tube which is inserted into the middle ear. 4 mgm (0.1 ml) of Gentamicine sulphate are instilled every 5 hours until the labyrinth begins to show a reaction. After this treatment 95 per cent of patients no longer suffer from vertigo and tinnitus and the pressure feeling are favourably influenced. The hearing mainly remains unchanged, but sometimes may even improve.
Insights
Gentamicin sulphate ear drops effectively treat Meniere
Area of Science:
- Otolaryngology
- Nephrology
- Pharmacology
Context:
- Meniere's disease is a challenging inner ear disorder.
- Current treatments for Meniere's disease have limitations.
Purpose:
- To evaluate the efficacy of Gentamicin sulphate for Meniere's disease.
Summary:
- Gentamicin sulphate was instilled into the middle ear via a plastic tube.
- 4 mg (0.1 ml) of Gentamicin sulphate was administered every 5 hours until labyrinthine reaction.
- 95% of patients experienced significant relief from vertigo, tinnitus, and pressure sensations.
Impact:
- This treatment offers a highly effective solution for Meniere's disease symptoms.
- Hearing preservation or improvement was observed in some patients.

