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Ischaemic heart disease and aged patients: effects of ascorbic acid on lipoproteins

J Horsey, B Livesley, J W Dickerson

    Journal of Human Nutrition
    |February 1, 1981
    PubMed

    Insights

    This study found that ascorbic acid deficiency is linked to abnormal cholesterol and triglyceride levels in older adults with ischaemic heart disease (IHD). Supplementation improved HDL-cholesterol and other lipid markers, suggesting it

    Area of Science:

    • Cardiology
    • Nutritional Science
    • Gerontology

    Background:

    • Aged individuals with ischaemic heart disease (IHD) often exhibit dyslipidemia, including elevated triglycerides and reduced high-density lipoprotein (HDL) cholesterol.
    • Subnormal levels of leucocyte ascorbic acid (vitamin C) were observed in a significant portion of IHD patients.
    • Initial leucocyte ascorbic acid levels showed a positive correlation with HDL-cholesterol in men, but not in women.

    Purpose of the Study:

    • To investigate the relationship between ascorbic acid levels and lipoprotein metabolism in aged individuals with IHD.
    • To evaluate the effects of ascorbic acid supplementation on lipid profiles in this population.

    Main Methods:

    • Cross-sectional analysis of lipid profiles and leucocyte ascorbic acid levels in aged men and women with IHD compared to controls.
    • Intervention study involving six weeks of ascorbic acid treatment in IHD patients.
    • Measurement of total serum cholesterol, HDL-cholesterol, LDL-cholesterol, and VLDL-triglycerides before and after treatment.

    Main Results:

    • Ascorbic acid supplementation increased HDL-cholesterol in all treated men and women with IHD.
    • In men with IHD, total serum cholesterol and LDL-cholesterol concentrations decreased after treatment.
    • In women with IHD, total serum cholesterol and VLDL-triglycerides were reduced following ascorbic acid supplementation.

    Conclusions:

    • Ascorbic acid deficiency may contribute to lipoprotein metabolism disorders in the elderly.
    • Latent ascorbic acid deficiency could be a preventable risk factor for the epidemic of IHD in Western countries.
    • Vitamin C supplementation shows potential therapeutic benefits for lipid abnormalities in aged IHD patients.

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