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Extended solubility approach: solubility parameters for crystalline solid compounds

A Martin, J Carstensen

    Journal of Pharmaceutical Sciences
    |February 1, 1981
    PubMed
    Summary
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    A new quadratic equation method determines solubility parameters for solid compounds. This approach refines the Hildebrand method, enabling easier calculation of drug solubility in various solvents.

    Area of Science:

    • Physical Chemistry
    • Materials Science

    Background:

    • Solubility parameters are crucial for predicting compound interactions and formulating solutions.
    • Existing models like the Hildebrand approach have limitations for crystalline solids.

    Purpose of the Study:

    • To develop a novel method for calculating solubility parameters of crystalline solids.
    • To improve the prediction of drug solubility in homologous solvent series.

    Main Methods:

    • A quadratic equation modifying the Scatchard-Hildebrand solubility expression was employed.
    • The geometric mean (delta 1 delta 2) was replaced with w12 = K delta 1 delta 2.
    • Logarithmic solubility terms were regressed against delta 1 using a second-degree power series for parabens and benzoic acid in alcohols.

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    Main Results:

    • The method successfully yielded reasonable solubility parameters for solid solutes.
    • It demonstrated a convenient approach for calculating solubility in a series of normal alcohols.

    Conclusions:

    • The proposed quadratic equation method offers an effective way to determine solubility parameters for crystalline solids.
    • This advancement facilitates the prediction of drug solubility, aiding in formulation development.