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Diabetic lymphangiopathy. An optical and electron microscopic study
Lymphology
|December 1, 1980
Summary
Diabetic leg lymphatic capillaries show endothelial and basal membrane damage, increasing permeability. These changes are significant in diabetic microangiopathy.
Area of Science:
- Vascular biology
- Diabetology
- Pathology
Background:
- Diabetes mellitus can lead to serious vascular complications.
- Diabetic macroangiopathy is associated with microvascular changes.
Purpose of the Study:
- To investigate morphopathological modifications in lymphatic capillaries of the leg tegument in diabetic patients.
- To understand the ultrastructural changes in the endothelium and basal membrane.
Main Methods:
- Ultrastructural examination of lymphatic capillaries from the dorsal side of the leg.
- Morphopathological analysis of endothelial and basal membrane alterations.
Main Results:
- Observed dilatations of intercellular space, endothelial dislocation/desquamation, increased micropinocytic vesicles, and intracellular vacuoles/lysosomes.
- These ultrastructural changes indicate increased endothelial permeability.
Conclusions:
- Morphopathological modifications in lymphatic capillaries are evident in diabetic patients, particularly those with macroangiopathy.
- Increased endothelial permeability is a key phenomenon in diabetic microangiopathy.