Related Experiment Video
Updated: Jul 25, 2026

Visualizing the Interrenal Steroidogenic Tissue and Its Vascular Microenvironment in Zebrafish
Published on: December 21, 2016
Age-dependent changes in rat liver steroid hormone receptor proteins
Abstract:
The formation of the steroid hormone-receptor protein complex in rat liver cytosol was investigated as a function of rat age. As reported earlier there was no age-related change in the concentration of receptor proteins in rat liver cytosol. The affinity of the specific receptor protein for both dexamethasone and corticosterone, however, decreased with age. An age-related decrease was observed in the concentration of steroid hormones that were associated with the specific receptor protein responsible for translocation of the nucleus. A reciprocal age-dependent increase in non-specific protein binding of the hormone occurred.
Related Concept Videos
Intracellular Hormone Receptors
Cell Specific Gene Expression
Regulation of Nuclear Protein Sorting
Transducer Mechanism: Nuclear Receptors
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Pharmacodynamics in Geriatric Patients: Effects of Age

