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Ibuprofen induced hyponatraemia

M Blum, A Aviram

    Rheumatology and Rehabilitation
    |November 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    A 55-year-old woman with chronic renal failure experienced severe hyponatremia after taking ibuprofen. Symptoms resolved upon drug discontinuation, highlighting potential risks in patients with kidney impairment.

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    Area of Science:

    • Nephrology
    • Clinical Pharmacology

    Background:

    • Chronic renal failure (CRF) predisposes patients to electrolyte imbalances.
    • Pyelonephritis is a common cause of CRF.
    • Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can affect renal function.

    Observation:

    • A 55-year-old female patient with advanced CRF secondary to pyelonephritis was treated with ibuprofen 400 mg/day for 3 days.
    • The patient developed severe hyponatremia during ibuprofen therapy.
    • Symptoms of hyponatremia and the low sodium levels resolved after discontinuing ibuprofen.

    Findings:

    • Ibuprofen administration can precipitate severe hyponatremia in patients with advanced chronic renal failure.
    • The likely mechanism involves impaired renal water excretion due to NSAID effects on kidney function.

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  • Discontinuation of ibuprofen led to the normalization of serum sodium levels.

    • Implications:

    • Clinicians should exercise caution when prescribing ibuprofen to patients with compromised renal function.
    • Monitoring of electrolytes, particularly sodium, is crucial in patients with CRF receiving NSAIDs.
    • This case underscores the potential for NSAID-induced hyponatremia in vulnerable populations.