[Skeletal fluorosis in senility (author's transl)]

Area of Science:

• Endocrinology
• Bone Metabolism
• Toxicology

Background:

• Osteoporosis treatment often involves sodium fluoride.
• Non-occupational exposure to fluoride can lead to skeletal fluorosis.
• Senility may present unique challenges in managing fluoride toxicity.

Observation:

• Two cases of nonprofessional skeletal fluorosis in elderly patients are presented.
• Detailed clinical and radiological findings were documented.
• Histological examination and bone fluoride content analysis were performed.

Findings:

• The study specifies the causes of origin for skeletal fluorosis in these cases.
• Bone fluoride levels were elevated, correlating with the observed pathology.
• The findings are discussed in the context of sodium fluoride therapy for osteoporosis.

Implications:

• Highlights potential risks of sodium fluoride therapy in susceptible elderly individuals.
• Underscores the importance of monitoring fluoride levels in patients undergoing long-term treatment.
• Suggests a need for revised treatment protocols or patient selection criteria for osteoporosis management.