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Postictal pleocytosis

J W Schmidley, R P Simon

    Annals of Neurology
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Generalized convulsions can cause temporary cerebrospinal fluid (CSF) pleocytosis, an increase in white blood cells. This finding suggests seizures alone may trigger this condition, even without infection.

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    Area of Science:

    • Neurology
    • Neuroscience
    • Clinical Medicine

    Background:

    • Cerebrospinal fluid (CSF) pleocytosis is often associated with infections or inflammation.
    • Generalized convulsions can have various underlying causes.

    Observation:

    • Six patients presented with transient CSF pleocytosis after repeated generalized seizures.
    • No infectious, inflammatory, or neoplastic causes were identified.
    • CSF analysis revealed mild to moderate leukocyte elevation, normal pressure, and protein levels.

    Findings:

    • A transient increase in CSF leukocytes (pleocytosis) was observed in patients following generalized convulsions.
    • The pleocytosis appeared unrelated to infection, inflammation, or neoplastic processes.
    • Leukocyte counts peaked post-seizure, suggesting a direct effect of convulsions.

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    Implications:

    • Seizures alone may induce a temporary breakdown of the blood-brain barrier, leading to CSF pleocytosis.
    • Clinicians should consider seizures as a potential cause of unexplained CSF pleocytosis.
    • This finding may refine diagnostic approaches for neurological conditions.