Squamous cell carcinoma arising in a linear epidermal nevus

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Linear epidermal nevus is a congenital skin condition.
• Squamous cell carcinoma (SCC) is a common skin cancer.
• SCC arising in epidermal nevi is exceptionally rare.

Observation:

• A 17-year-old female presented with a 4-month history of an isolated, pruritic right breast lesion.
• The lesion was erythematous, indurated, hyperkeratotic, and well-circumscribed.
• Histological examination revealed well-differentiated squamous cell carcinoma within a linear epidermal nevus.

Findings:

• This case represents an unusual occurrence of squamous cell carcinoma developing in a linear epidermal nevus.
• The patient's young age and the lesion's short duration are atypical for this rare phenomenon.
• No predisposing factors were identified for the development of the cancer.

Implications:

• This case underscores the potential for malignant transformation in epidermal nevi, even in young individuals.
• Early detection and monitoring of congenital skin lesions are crucial for identifying potential malignancies.
• Further research is needed to understand the specific risk factors and mechanisms involved in SCC development within epidermal nevi.