Electrophoretic pattern of proteins in mammary gland neoplasias

Protein pattern was studied using discontinuous polyacrylamide gel electrophoresis in 53 adenocarcinomas, 13 fibroadenomas and 66 samples of mammary tissue adjacent to neoplasias. Important differences were found in patterns of both types of neoplasias, the same as between malignant tissues and non neoplastic adjacent tissues. There seems to be a certain correlation between some protein pattern and NOS and lobular histological types. It was also observed that some protein patterns were more frequent in neoplasias with metastasis to axillary nodes and vascular invasion. On the other hand, there seems to be important correlation between some protein patterns and the presence of early tumoral activity after mastectomy that is present even in the absence of positive axillary nodes at the moment of surgery.