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Iris angiography and aqueous photofluorometry in normal subjects
Archives of Ophthalmology (Chicago, Ill. : 1960)
|March 1, 1981
Summary
Aging may alter eye membrane permeability, affecting aqueous humor dynamics. Iris angiography revealed pupillary leakage in 20% of subjects, and older individuals showed higher aqueous fluorescein concentrations.
Area of Science:
- Ophthalmology
- Physiology
Background:
- Iris angiography and aqueous photofluorometry are diagnostic tools.
- Understanding age-related changes in ocular physiology is crucial.
Purpose of the Study:
- To investigate age-related changes in iris vasculature and aqueous humor dynamics.
- To assess the correlation between Hemoglobin A1c levels and aqueous fluorescein concentration.
Main Methods:
- Iris angiography and aqueous photofluorometry performed on 44 normal subjects (age 15-65).
- Hemoglobin A1c levels measured in 20 participants.
- Analysis of dye leakage from pupillary margin and radial iris vessels.
Main Results:
- Pupillary margin leakage observed in 20% of eyes, with rapid dye fading.
- No leakage from radial iris vessels.
- Aqueous fluorescein concentration at 60 minutes significantly increased with age.
- Hemoglobin A1c levels correlated significantly with aqueous fluorescein concentration.
Conclusions:
- Age-associated alterations in biologic membrane permeability may affect ocular fluid dynamics.
- Findings suggest potential changes in the blood-aqueous barrier with aging.