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Updated: Aug 9, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Summary
Follicular psoriasis presents in two distinct forms: a widespread adult type and plaque-like lesions in children. Histology reveals hair follicle involvement, suggesting it
Area of Science:
- Dermatology
- Pathology
Background:
- Psoriasis is a chronic inflammatory skin condition.
- Follicular involvement in psoriasis is not well-characterized.
Purpose of the Study:
- To describe the clinical and histological features of follicular psoriasis.
- To investigate the role of the hair follicle in psoriatic lesions.
Main Methods:
- Case report of ten patients with follicular psoriasis.
- Clinical observation of lesion presentation in adults and children.
- Histopathological examination of early and older psoriatic lesions.
Main Results:
- Two distinct clinical types identified: adult (widespread, thigh lesions) and pediatric (plaque-like, trunk lesions).
- Early lesions showed dermal infiltrate with prominent mast cells and normal hair follicles.
- Older lesions exhibited nucleated cells in the hair follicle ostium.
Conclusions:
- Follicular psoriasis presents with unique clinical and histological characteristics.
- The hair follicle appears to be affected in psoriatic skin disease.
- Further research is warranted to understand the pathogenesis of follicular psoriasis.
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