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Increased prolactin reserve in alcoholics

A Basile, G Proto, N Laperchia

    Drug and Alcohol Dependence
    |February 1, 1981
    PubMed
    Summary
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    Chronic alcoholics show a heightened prolactin response to metoclopramide, even without liver disease. This suggests alcohol withdrawal may impact prolactin regulation via dopaminergic pathways.

    Area of Science:

    • Endocrinology
    • Neuroscience
    • Hepatology

    Background:

    • Alcohol consumption can affect hormonal regulation.
    • Dopaminergic pathways are implicated in both alcohol dependence and prolactin secretion.
    • The impact of alcohol withdrawal on endocrine function requires further elucidation.

    Purpose of the Study:

    • To investigate the prolactin response to metoclopramide in chronic alcoholics.
    • To determine if liver disease influences this response.
    • To explore potential mechanisms behind observed hormonal changes.

    Main Methods:

    • Oral administration of metoclopramide (10 mg) to 53 chronic alcoholics.
    • Assessment of prolactin levels in patients 2-7 days after alcohol cessation.
    • Comparison of patient responses to a control group of healthy individuals.

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  • Stratification of patients based on the presence or absence of alcoholic cirrhosis.

    • Main Results:

    • Chronic alcoholics exhibited a significantly higher prolactin response to metoclopramide compared to healthy controls.
    • The elevated prolactin response was observed irrespective of the presence or severity of alcoholic liver disease.
    • No correlation was found between the degree of liver damage and the magnitude of the prolactin response.

    Conclusions:

    • Alcohol withdrawal appears to enhance the prolactin secretory capacity.
    • The observed phenomenon may be linked to altered dopaminergic activity following alcohol cessation.
    • Ethanol's direct effect on prolactin secretion cannot be excluded as a contributing factor.