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Model of intraabdominal abscess in mice
Infection and Immunity
|January 1, 1981
Abstract:
Intraperitoneal inoculation of sterile mouse feces into mice produced intraabdominal abscesses. The addition of Bacteroides fragilis increased the incidence and the number of abscesses.
Insights
Sterile mouse feces injected into mice caused intraabdominal abscesses. Adding Bacteroides fragilis significantly increased the occurrence and severity of these abscesses, highlighting its role in infection.
Area of Science:
- Microbiology
- Infectious Diseases
- Animal Models
Background:
- Intraabdominal abscesses are serious complications.
- The role of specific gut bacteria in abscess formation requires further elucidation.
Purpose of the Study:
- To investigate the potential of sterile mouse feces to induce intraabdominal abscesses in a murine model.
- To determine the impact of Bacteroides fragilis on the incidence and severity of experimentally induced intraabdominal abscesses.
Main Methods:
- Intraperitoneal inoculation of sterile mouse feces into a cohort of mice.
- Assessment of abscess formation and quantification.
- Evaluation of the effect of co-inoculation with Bacteroides fragilis.
Main Results:
- Intraperitoneal administration of sterile mouse feces successfully induced intraabdominal abscesses in mice.
- The presence of Bacteroides fragilis markedly elevated both the frequency and the number of abscesses observed.
Conclusions:
- Sterile fecal material can initiate intraabdominal abscesses.
- Bacteroides fragilis plays a significant role in promoting the development and progression of intraabdominal abscesses in this model.