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[Eruptive keratoacanthoma]

W Sterry, G K Steigleder, H Pullmann

    Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
    |March 1, 1981
    PubMed
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    Eruptive keratoacanthomas, a skin condition, present with numerous papules and inflammation. Treatment with aromatic retinoid Ro 10-9359 showed a positive therapeutic response.

    Area of Science:

    • Dermatology
    • Oncology

    Background:

    • Keratoacanthomas are common skin tumors.
    • Eruptive keratoacanthomas present as sudden, widespread papules.

    Observation:

    • A 74-year-old woman presented with eruptive keratoacanthomas, masked facies, ectropion, and pruritus.
    • Histology confirmed the characteristic architecture of keratoacanthoma.
    • Ultrastructural analysis revealed intracellular desmosomes and dermal fibers.

    Findings:

    • Cell division increased in the basal layer, with prolonged DNA synthesis time (15.7 h) and decreased generation time.
    • The dermal infiltrate was predominantly lymphocytic.
    • Aromatic retinoid Ro 10-9359 demonstrated therapeutic efficacy.

    Implications:

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    • Understanding keratoacanthoma proliferation kinetics aids in treatment strategies.
    • Aromatic retinoids show promise for managing eruptive keratoacanthomas.
    • Further research into ultrastructural features may reveal new therapeutic targets.