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Changes in circulating steroids with aging in postmenopausal women

D R Meldrum, B J Davidson, I V Tataryn

    Obstetrics and Gynecology
    |May 1, 1981
    PubMed
    Summary

    Aging significantly impacts adrenal androgens in postmenopausal women, with levels of dehydroepiandrosterone declining. However, cortisol, progestins, and testosterone levels remain stable, unaffected by age.

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    Area of Science:

    • Endocrinology
    • Gerontology
    • Reproductive Health

    Background:

    • Menopause is associated with significant hormonal changes.
    • Understanding age-related alterations in steroid hormones is crucial for women's health.
    • Previous research has yielded conflicting results on aging's effect on hormone levels.

    Purpose of the Study:

    • To investigate the impact of aging on circulating steroid hormone concentrations in postmenopausal women.
    • To compare hormone levels in postmenopausal women across a wide age range.
    • To elucidate age-related changes in specific steroid hormone classes.

    Main Methods:

    • Blood samples were collected from 155 postmenopausal women aged 34-83 with spontaneous ovarian failure.
    • Concentrations of various steroid hormones, including C-21 steroids, progestins, androgens, cortisol, estradiol (E2), and estrone (E1), were measured.

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  • Statistical analyses were performed to assess the correlation between hormone levels and age, as well as body weight.

    • Main Results:

    • Levels of pregnenolone, 17-hydroxypregnenolone, progesterone, 17-hydroxyprogesterone, and cortisol did not change with age.
    • Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) significantly declined with age (P < .001).
    • Androstenedione and testosterone levels showed no age-related changes; E2 and E1 levels correlated with body weight but not age.

    Conclusions:

    • Progestin production is not affected by age, apart from the loss of ovarian corpus luteum function.
    • The decline in delta-5 androgens suggests an age-related decrease in adrenal 17,20 desmolase activity.
    • Estradiol and estrone levels reflect body size's effect on peripheral aromatization, not age itself.