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Lamella-particle complexes in the human placenta

J C Sutherland, E B Middleton, W G Banfield

    Pathology, Research and Practice
    |November 1, 1980
    PubMed
    Summary
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    Lamella-particle complexes, resembling those in blood cancers, were found in placental pericytes. Their presence in human placentas is infrequent and its cause remains unknown.

    Area of Science:

    • Obstetrics and Gynecology
    • Cell Biology
    • Pathology

    Background:

    • Lamella-particle complexes are characteristic of human hematopoietic malignancies.
    • Pericytes are crucial cells in placental villi, regulating blood flow and maternal-fetal exchange.

    Purpose of the Study:

    • To investigate the presence and morphology of lamella-particle complexes in human placental pericytes.
    • To determine if these complexes correlate with pregnancy complications or patient factors.

    Main Methods:

    • Human placental tissues from normal and complicated pregnancies were examined using electron microscopy.
    • Morphometric analysis was performed on identified lamella-particle complexes.

    Main Results:

    • Lamella-particle complexes were observed in pericytes of 2 out of 10 placentas.

    Related Experiment Videos

  • These complexes measured 0.37-0.75 micrometers in diameter, featuring concentric layers of lamellae and particles around central cores.
  • The presence of these complexes did not correlate with parity or drug treatment.

    • Conclusions:

    • The study identified lamella-particle complexes in human placental pericytes, structures previously associated with malignancies.
    • The infrequent occurrence and unknown etiology of these complexes in placentas warrant further investigation.