[Use of experimental models in osteoarticular infections]

Animal experimental models are necessary to study a certain number of factors affecting the course and treatment of bone and joint infections: virulence of the bacteria, presence of foreign bodies or blood-stained effusion, administration of corticosteroids, mode of action of antibiotics. Whereas the penetration of antibiotics within the joint is excellent, it is variable during bony infections and the association of two bactericidal antibiotics and prolonged treatment are necessary to sterilise the infected bone. Although the information supplied by experimental models may be fundamental, it cannot be extrapolated to man without certain precautions.