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Antiviral effect of haloperidol on Rauscher murine leukemia virus

V Wunderlich, F Fey, G Sydow

    Archiv Fur Geschwulstforschung
    |January 1, 1980
    PubMed

    Insights

    The neuroleptic drug haloperidol (Hal) effectively combats Rauscher leukemia virus in mice. It significantly reduces spleen enlargement and extends survival, suggesting a direct antiviral action.

    Area of Science:

    • Pharmacology
    • Virology
    • Oncology

    Background:

    • Rauscher leukemia virus (RLV) causes splenomegaly and mortality in mice.
    • Neuroleptic drugs are typically used for psychiatric conditions.

    Purpose of the Study:

    • To investigate the potential antiviral activity of haloperidol (Hal) against Rauscher leukemia virus.
    • To determine if Hal can inhibit RLV-induced splenomegaly and improve survival rates.

    Main Methods:

    • Male NMRI mice were inoculated with Rauscher leukemia virus.
    • Haloperidol was administered via intraperitoneal or intravenous injections starting 5 hours post-inoculation.
    • Effects on splenomegaly and mean survival time were assessed.

    Main Results:

    • Haloperidol demonstrated significant inhibition of virus-induced splenomegaly.
    • Administration of haloperidol markedly prolonged the mean survival time of infected mice.
    • Evidence suggests a direct interaction between haloperidol and the Rauscher leukemia virus.

    Conclusions:

    • Haloperidol exhibits potent antiviral activity against Rauscher leukemia virus.
    • The drug's mechanism involves a direct action on the virus, not just host-mediated effects.
    • Haloperidol represents a potential therapeutic agent for RLV infections.

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