[Oscillations and resonance phenomena in the simple, open enzymatic reaction--S-E-P-- reacting with an enzyme-forming...

Resonance phenomena in a simple open biochemical reaction were studied under conditions of a continuous enzyme flow through the reaction maintained by the enzyme-producing system (EPS). Periodical disturbance of the rate of substrate influx may bring about a resonance effect in the reaction, the amplitude of forced sustained oscillations being maximal at a frequency close to that of the system itself. Additional resonance effects may appear due to nonlinearity of the system at frequencies multiple (or close to multiple) of the own frequency, as well as at subfrequencies. Near own frequency and its double value, hysteresis may occur, in which case the amplitude of forced sustained oscillations will alternate between two possible values.