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Updated: Oct 13, 2026

Gastrointestinal Motility Monitor (GIMM)
Published on: December 1, 2010
Peristalsis abolishes the release of methionine-enkephalin from guinea-pig ileum in vitro
Abstract:
The release of methionine-enkephalin from superfused guinea-pig ileum has been demonstrated. Methionine-enkephalin, as measured by radioimmunoassay, was shown to be released from tissues maintained at an intraluminal pressure of O cm water (resting conditions). Increased intraluminal pressure (5 cm water) induced peristalsis and abolished the release of methionine-enkephalin. These results provide further evidence that endogenous opioids may be involved in the modulation of contractile activity in the guinea-pig ileum.
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