Related Experiment Videos
[Animal studies on ribostamycin (author's transl)]
Immunitat Und Infektion
|April 1, 1981
Summary
Ribostamycin exhibits lower nephrotoxicity than gentamicin in rats, with reduced toxicity when co-administered with D-glucaro-delta-lactam. However, ribostamycin showed inferior efficacy in treating pyelonephritis.
Area of Science:
- Pharmacology and Toxicology
- Nephrology
- Infectious Diseases
Background:
- Aminoglycoside antibiotics, including ribostamycin, are crucial for treating bacterial infections.
- Nephrotoxicity is a significant concern with aminoglycoside use, necessitating careful evaluation.
- Understanding the pharmacokinetic and pharmacodynamic properties of ribostamycin is essential for optimizing its clinical application.
Purpose of the Study:
- To assess the nephrotoxicity, pharmacokinetics, and therapeutic efficacy of ribostamycin in a rat model.
- To compare the nephrotoxic potential of ribostamycin with gentamicin.
- To investigate the protective effect of D-glucaro-delta-lactam against ribostamycin-induced nephrotoxicity.
Main Methods:
- Nephrotoxicity was evaluated by measuring urinary excretion of tubular cells and malate dehydrogenase in rats.
- Ribostamycin was administered via intravenous (i.v.) and intramuscular (i.m.) routes.
- D-glucaro-delta-lactam was co-administered with ribostamycin to assess its protective effects.
- Renal concentrations of ribostamycin were measured after single and repeated dosing.
- Therapeutic efficacy was determined in a rat model of acute pyelonephritis.
Main Results:
- Intravenous and intramuscular administration of ribostamycin resulted in comparable tubular cell excretion.
- Co-administration with D-glucaro-delta-lactam significantly reduced the nephrotoxic effects of ribostamycin.
- Ribostamycin demonstrated lower nephrotoxicity compared to gentamicin, with a higher dose required to induce tubular cell loss.
- Lower renal ribostamycin concentrations were observed compared to gentamicin.
- Ribostamycin was less effective than gentamicin in treating experimental acute pyelonephritis at tested dosages.
Conclusions:
- Ribostamycin exhibits a lower nephrotoxic profile than gentamicin in rats.
- D-glucaro-delta-lactam can mitigate ribostamycin-induced nephrotoxicity.
- Despite its favorable safety profile, ribostamycin's therapeutic efficacy in acute pyelonephritis is inferior to gentamicin.