Intratumor distribution of blood flow and of vascular volume in a transplantable rat sarcoma

The intratumor distribution of plasma volume and of blood flow was studied simultaneously by radioisotope techniques in a transplantable, slightly differentiated 20-methylcholanthrene-induced rat sarcoma. A significant change toward lower tumor blood flow was found in the sarcoma with increasing tumor growth, accompanied by a reduced plasma volume. The distributions of plasma volume and blood flow were similar in peripheral and central parts of tumors. However, no significant correlation between plasma volume and blood flow was found in separate tumor specimens.