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Related Experiment Videos

Whither Westergren--the sedimentation rate reevaluated

D C Belin, E Morse, A Weinstein

    The Journal of Rheumatology
    |March 1, 1981
    PubMed
    Summary

    The Westergren sedimentation rate test lacks standardization, with varied methods used. Reproducible results are achieved with classical or modified Westergren techniques, not undiluted blood.

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    Area of Science:

    • Clinical Chemistry
    • Hematology
    • Rheumatology

    Background:

    • The Westergren sedimentation rate is a common diagnostic marker.
    • Variability in testing methods may affect clinical interpretation.
    • Standardization is crucial for reliable diagnostic results.

    Purpose of the Study:

    • To assess the standardization of the Westergren sedimentation rate test.
    • To compare the reproducibility of different Westergren methods.
    • To identify the most reliable Westergren technique.

    Main Methods:

    • Survey distributed to rheumatologists and clinical laboratory directors.
    • Comparative study of different Westergren sedimentation rate techniques.
    • Analysis of results from classical Westergren, modified Westergren (EDTA/saline), and undiluted whole blood methods.

    Main Results:

    • Significant variation in Westergren sedimentation rate techniques was observed.
    • Classical Westergren and modified Westergren (EDTA/saline) yielded the most reproducible results.
    • Undiluted whole blood Westergren method showed poor reproducibility.

    Conclusions:

    • The Westergren sedimentation rate test is not consistently standardized.
    • Modified Westergren techniques offer improved reproducibility.
    • Specifying the exact method used is essential for clinical studies and accurate diagnosis.

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