HLA-DR antigens in pemphigus among Japanese

The frequency of HLA-DR4 was significantly increased at P less than 0.02 in 37 unrelated pemphigus patients (62.2%), when compared with unrelated 73 healthy controls (30.1%). This antigen was more frequently found in pemphigus foliaceus (70.6%) than pemphigus vulgaris (55.8%).