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Updated: Aug 10, 2026
09:44
Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
Published on: September 11, 2012
[Kanamycin pharmacokinetics in experimental small intestine obstruction]
Antibiotiki
|March 1, 1981
Summary
Intramuscular kanamycin effectively penetrates into the blood, lymph, and small intestine tissues in dogs with ileus. Peak antibiotic concentrations in all tested biosubstrates were observed within one hour post-administration.
Area of Science:
- Veterinary Pharmacology
- Surgical Research
- Pharmacokinetics
Context:
- Occlusive ileus in dogs presents challenges for drug delivery to affected tissues.
- Understanding antibiotic distribution is crucial for effective treatment protocols.
- Kanamycin is an antibiotic used in veterinary medicine.
Purpose:
- To investigate the pharmacokinetic profile and tissue distribution of kanamycin administered intramuscularly in dogs with induced ileus.
- To assess the penetration of kanamycin into blood, lymph, peritoneal fluid, and intestinal tissues.
- To determine the optimal timing for peak antibiotic concentration.
Summary:
- Dogs with 48-hour occlusive ileus received intramuscular kanamycin (30 mg/kg) one hour before surgery.
- High kanamycin concentrations were found in blood, lymph, and the small intestinal vascular system.
- Approximately 50% of blood concentration was detected in peritoneal exudate, and up to 20% in intestinal walls, mesentery, and peritoneum.
- Peak antibiotic levels in all measured biosubstrates occurred at 1 hour post-injection.
Impact:
- Provides essential pharmacokinetic data for optimizing kanamycin dosing in veterinary surgical patients with ileus.
- Highlights the potential efficacy of intramuscular kanamycin in reaching target tissues despite intestinal obstruction.
- Informs clinical decisions regarding antibiotic selection and administration timing in similar surgical scenarios.
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