Influence of levamisole treatment in old people

Eight hospitalized people, over 77 years old, have been treated during one month with Levamisole at the dose of 150 mg a day, once a week. They have been compared to 18 controls matched for age. Levamisole raised the number of E rosettes in aged patients. This effect was found to be significant. However the increase of the percentage of E rosettes was not comparable to the percentage found in young healthy subjects. In three subjects the administration of the drug resulted in a fall of auto-antibodies noted before therapy.