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[Determination of creatine kinase and CK-MB in heart failure (author's transl)]
Insights
Serum creatine kinase-MB (CK-MB) elevations occurred in 19 patients with overt heart failure, particularly those with inflammatory heart disease. CK-MB levels did not correlate with heart failure severity but may indicate myocardial changes.
Area of Science:
- Biochemistry
- Cardiology
- Clinical Medicine
Context:
- Investigated serum creatine kinase (CK) and CK-MB activity in 129 patients with overt heart failure of diverse etiologies.
- Focused on the diagnostic and prognostic implications of CK-MB elevation in heart failure patients.
Purpose:
- To determine the frequency and significance of elevated serum CK-MB in patients with overt heart failure.
- To explore the relationship between CK-MB levels, heart failure severity, and underlying myocardial processes.
Summary:
- Elevated serum CK-MB was observed in 19 out of 129 patients (14.7%), most commonly in those with inflammatory heart disease.
- No significant correlation was found between serum CK-MB activity and the severity of heart failure.
- CK-MB elevation in chronic heart failure may reflect ongoing progressive or regressive myocardial changes.
Impact:
- Suggests that CK-MB elevation in heart failure, especially inflammatory types, warrants further investigation.
- Highlights that CK-MB levels alone are not a reliable indicator of heart failure severity.
- Provides insights into the dynamic nature of myocardial remodeling in heart failure.
Abstract:
Serum activity of creatine kinase and creatine kinase-MB have been investigated in 129 patients of various etiology in overt heart failure. Elevations in CK-MB were found in 19 patients, most frequently in patients with inflammatory heart disease. We found no correlation between CK-MB activity in serum and the severity of heart failure. CK-MB elevation in patients with chronic heart failure may be interpreted as a sign of progressive as well as regressive processes in the myocardium.